Endothelin-1 increases osteoclastic bone resorption via endothelin A receptors during orthodontic tooth movement in rats
نویسندگان
چکیده
Address: 1Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia, 2Ortline, Institute for Orthodontics and General Dentistry, 1000 Ljubljana, Slovenia, 3Department of Orthodontics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia, 4Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia and 5Department of Medical and Natural Sciences, College of Health Care, University of Primorska, 6000 Koper, Slovenia
منابع مشابه
The effects of TBC3214, a selective endothelin ETA receptor antagonist, on orthodontic tooth movement in rats.
Many chemical messengers are involved in the process of alveolar bone and periodontal ligament remodelling during orthodontic tooth movement. Among them is probably endothelin-1 (ET-1). Its role in this process has been partly explained using tezosentan, which affects endothelin A (ET(A)) and endothelin B (ET(B)) receptors. Tezosentan enhances orthodontic tooth movement. The aim of this study w...
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OBJECTIVE Tramadol is a synthetic analgesic of opioids which has more flexible mechanisms of action than typical opioids. Since it has been reported in previous study that typical opioids like morphine can affect the bone homeostasis, it is worthwhile to examine the effects of tramadol on tooth movement. In this study we investigated effects of tramadol on orthodontic tooth movement in rats. ...
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The purpose of this article was reviewing the literature related to the mutual effects of endodontics and orthodontics on each other providing documented information that can be used by dentists in clinical practice. The effect of orthodontic treatment on the dental pulp and its role in root resorption, the influence of previous trauma to the tooth and endodontic treatment in orthodontic tooth ...
متن کاملLocal and chronic application of PTH accelerates tooth movement in rats.
We previously reported that whereas systemic continuous infusion of parathyroid hormone (PTH) accelerated orthodontic tooth movement, systemic but intermittent injection of PTH did not increase the rate of tooth movement. Analysis of these data suggested that continuous administration of PTH could be applicable for orthodontic therapy. In the present study, we investigated whether local and chr...
متن کاملExpression levels of endothelin-1, endothelin-2, and endothelin-3 vary during the initial, lag, and late phase of orthodontic tooth movement in rats.
Endothelins (ET)-1, ET-2, and ET-3 are one group of cytokines likely to be released during orthodontic tooth movement (OTM). Therefore, the expression of ET levels was investigated to determine the importance and involvement of isopeptides during the several phases of OTM. Thirty-two male Wistar rats (12-13 weeks old) were divided into four groups of eight: control, 14, 28, and 42 day groups. T...
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